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Article

Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2012

Arcaroli John J, Quackenbush Kevin S, Powell Rebecca W, Pitts Todd M, Spreafico Anna, Varella-Garcia Marileila, Bemis Lynne, Tan Aik Choon, Reinemann Jaclyn M, Touban Basel M, Dasari Arvind, Eckhardt S Gail, Messersmith Wells A

Abstract excerpt

PURPOSE: Dysregulation of the phosphoinositide 3-kinase (PI3K) and Src signaling pathways commonly occur in colorectal cancer. Mutations in the PIK3CA gene are associated with an increase in severity of disease and worse clinical outcomes. Elevated levels of Src have been identified in premalignant lesions and are suggested to play a central role in tumor progression. Because these pathways appear to enhance...

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PMID: 22553375
DOI: 10.1158/1078-0432.CCR-11-3167
PMCID: PMC3836589

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