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Article

Study of the prothrombin gene 20201 GA variant in FV:Q506 carriers in relationship to the presence or absence of juvenile venous thromboembolism.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1999

Ehrenforth S, von Depka Prondsinski M, Aygören-Pürsün E, Nowak-Göttl U, Scharrer I, Ganser A

Abstract excerpt

The G20210A transition of the prothrombin gene has been identified as a common but probably mild hereditary risk factor for venous thromboembolism (VTE). However, the prothrombin gene variant might contribute to the penetrance of thromboembolic disease in many patients with other prothrombotic defects, such as the FV:R506Q mutation. In this investigation, the A20210 allele was found in 9 of 450 healthy controls...

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PMID: 9974407
DOI: 10.1161/01.atv.19.2.276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Study of the prothrombin gene 20201 GA variant in FV:Q506 carriers in relationship to the presence or absence of juvenile venous thromboembolism.PMID 9974407Read ↗

Prothrombin G20210A Gene Mutation and Further Prothrombotic Risk Factors in Childhood ThrombophiliaSemantic proximity Read ↗

Homozygotes for prothrombin gene 20210 A allele in a thrombophilic family without clinical manifestations of venous thromboembolism.Semantic proximity Read ↗

The prothrombin gene G20210A variant in an unselected thromboembolic population. A Belgian prospective clinical study.Semantic proximity Read ↗

Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia.Semantic proximity Read ↗

The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease.Semantic proximity Read ↗

Impact of the factor II: G20210A variant on the risk of venous thromboembolism in relatives from families with the factor V: R506Q mutation.Semantic proximity Read ↗

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.Semantic proximity Read ↗

Different outcome of six homozygotes for prothrombin A20210A gene variant.Semantic proximity Read ↗

Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210A/A prothrombin mutation and heterozygous 1691G/A factor V Leiden mutation.Semantic proximity Read ↗

The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis.Semantic proximity Read ↗

The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic populationSemantic proximity Read ↗

Prevalence of 20210 A allele of the prothrombin gene in venous thromboembolism patients.Semantic proximity Read ↗

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