Article
The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Ferraresi P, Marchetti G, Legnani C, Cavallari E, Castoldi E, Mascoli F, Ardissino D, Palareti G, Bernardi F
Abstract excerpt
A genetic variation in the 3'-untranslated region of the prothrombin mRNA (20210 G/A) has recently been reported to be associated with elevated plasma prothrombin levels and with an increased incidence of venous thrombosis. We determined the frequency of this mutation, the detection of which was...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Alleles
- Cerebrovascular Disorders
- Cohort Studies
- Comorbidity
- Coronary Disease
- Cyprus
- DNA Mutational Analysis
- Ethnicity
- Factor V
- Female
- Gene Frequency