Article
Homozygotes for prothrombin gene 20210 A allele in a thrombophilic family without clinical manifestations of venous thromboembolism.
Haematologica - 1 Jul 1999
Souto J C, Mateo J, Soria J M, Llobet D, Coll I, Borrell M, Fontcuberta J
Abstract excerpt
BACKGROUND AND OBJECTIVE: A new genetic risk factor for venous thromboembolism has recently been described which involves a G to A transition at position 20210 in the 3' untranslated region of the prothrombin gene. To date, only a few homozygotes for this mutation have been reported and in most of cases, they suffered from thrombotic disease. Here, we describe a pedigree including both heterozygous and homozygous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.