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Article

Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100

7 Apr 2011

Abstract excerpt

Nuclear domains 10 (ND10s) are discrete subnuclear structures that contain the three major protein components promyelocytic leukaemia protein (PML), hDaxx and Sp100. Previous studies identified the ND10-components PML and hDaxx as cellular restriction factors that independently counteract human cytomegalovirus (HCMV) infection via the repression of viral immediate-early (IE) gene expression. Consequently, we...

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PMID: 21471311
DOI: 10.1099/vir.0.030981-0

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