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Article

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.

The Journal of cell biology - 29 Dec 1997

Sternsdorf T, Jensen K, Will H

Abstract excerpt

PML and Sp100 proteins are associated with nuclear domains, known as nuclear dots (NDs). They were discovered in the context of leukemic transformation and as an autoantigen in primary biliary cirrhosis, respectively. Both proteins are expressed in the form of many COOH-terminally spliced variants, and their expression is enhanced by interferons (IFN). The recent finding that PIC1/SUMO-1, a small ubiquitin-like...

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Identifiers

PMID: 9412458
DOI: 10.1083/jcb.139.7.1621
PMCID: PMC2132645

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.PMID 9412458Read ↗

Small ubiquitin‐related modifiersSemantic proximity Read ↗

Two Nuclear Dot‐Associated Proteins, PML and SplOO, are Often Co‐Autoimmunogenic in Patients with Primary Biliary CirrhosisSemantic proximity Read ↗

Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif.Semantic proximity Read ↗

Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body DisruptionSemantic proximity Read ↗

Autoantibodies to the Nuclear Sp100 Protein in Primary Biliary Cirrhosis and Associated Diseases: Epitope Specificity and Immunoglobulin Class DistributionSemantic proximity Read ↗

Structural and Functional Heterogeneity of Nuclear BodiesSemantic proximity Read ↗

Host transcription factor Speckled 110 kDa (Sp110), a nuclear body protein, is hijacked by hepatitis B virus protein X for viral persistenceSemantic proximity Read ↗

The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartmentsSemantic proximity Read ↗

Interferon, restriction factors and SUMO pathwaysSemantic proximity Read ↗

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1Semantic proximity Read ↗

The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus.Semantic proximity Read ↗

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies.Semantic proximity Read ↗

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