Article
Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Gray C M, Lawrence J, Schapiro J M, Altman J D, Winters M A, Crompton M, Loi M, Kundu S K, Davis M M, Merigan T C
Abstract excerpt
Peptide/MHC tetrameric complexes were used to enumerate the frequency of HLA class I-restricted epitope-specific CD8+ T cells in 18 HLA-A*0201 HIV type 1-infected asymptomatic patients. HLA-A*0201 molecules were complexed to HIV Gag p17 (amino acids 77-85) and reverse transcriptase (amino acids 4...
Topics
- Amino Acid Sequence
- Anti-HIV Agents
- CD8-Positive T-Lymphocytes
- Epitopes
- Gene Products, gag
- HIV Antigens
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- HLA-A Antigens
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Peptide Fragments