Article
An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status.
Clinical immunology and immunopathology - 1 Oct 1993
Landay A L, Mackewicz C E, Levy J A
Abstract excerpt
We have examined the relation of cell surface marker phenotype to the anti-human immunodeficiency virus (HIV) function of CD8+ cells from individuals at various clinical stages of HIV infection. Multiparametric flow cytometry analysis demonstrated that the most significant changes in cell surface phenotype was found within the CD8+ cell subset expressing HLA-DR and CD28. These changes in the levels of CD28 and...
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