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Article

High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function.

European journal of immunology - 1 Mar 2001

Kostense S, Ogg G S, Manting E H, Gillespie G, Joling J, Vandenberghe K, Veenhof E Z, van Baarle D, Jurriaans S, Klein M R, Miedema F

Abstract excerpt

To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11241270
DOI: 10.1002/1521-4141(200103)31:3<677::aid-immu677>3.0.co;2-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11241270-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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