Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

doi:10.1002/j.1460-2075.1995.tb06976.x

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Article

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

The EMBO journal - 3 Jan 1995

Hardy S P, Goodfellow H R, Valverde M A, Gill D R, Sepúlveda V, Higgins C F

Abstract excerpt

The multidrug resistance P-glycoprotein (P-gp), which transports hydrophobic drugs out of cells, is also associated with volume-activated chloride currents. It is not yet clear whether P-gp is a channel itself, or whether it is a channel regulator. Activation of chloride currents by hypotonicity...

Topics

3T3 Cells
ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Sequence
Animals
Base Sequence
Cell Size
Chloride Channels
Chlorides
Consensus Sequence
Drug Resistance, Multiple
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Models, Molecular

Molecular Sequence Data

Mutation

Phosphorylation

Protein Kinase C

Source

Open in PubMed Open full text

Identifiers

PMID: 7828597
DOI: 10.1002/j.1460-2075.1995.tb06976.x
PMCID: PMC398053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7828597-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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