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Article

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

The EMBO journal - 3 Jan 1995

Hardy S P, Goodfellow H R, Valverde M A, Gill D R, Sepúlveda V, Higgins C F

Abstract excerpt

The multidrug resistance P-glycoprotein (P-gp), which transports hydrophobic drugs out of cells, is also associated with volume-activated chloride currents. It is not yet clear whether P-gp is a channel itself, or whether it is a channel regulator. Activation of chloride currents by hypotonicity in cells expressing P-gp was shown to be regulated by protein kinase C (PKC). HeLa cells exhibited volume-activated...

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Identifiers

PMID: 7828597
DOI: 10.1002/j.1460-2075.1995.tb06976.x
PMCID: PMC398053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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