Article
In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin.
Journal of translational medicine - 4 Aug 2015
Stellari Fabio, Bergamini Gabriella, Sandri Angela, Donofrio Gaetano, Sorio Claudio, Ruscitti Francesca, Villetti Gino, Assael Barouk M, Melotti Paola, Lleo Maria M
Abstract excerpt
BACKGROUND: Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in vivo is challenging and usually requires invasive methods. METHODS: Lung inflammation was induced using the culture supernatants from two Pseudomonas aeruginosa clinical strains, VR1 and VR2,...
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