Article
Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.
Infection and immunity - 1 Jul 2000
Pearson J P, Feldman M, Iglewski B H, Prince A
Abstract excerpt
Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.
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