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Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection.

Microbiology (Reading, England) - 1 May 2001

Wu Hong, Song Zhijun, Givskov Michael, Doring Gerd, Worlitzsch Dieter, Mathee Kalai, Rygaard Jørgen, Høiby Niels

Abstract excerpt

To understand the importance of quorum sensing in chronic Pseudomonas aeruginosa lung infection, the in vivo pathogenic effects of the wild-type P. aeruginosa PAO1 and its double mutant, PAO1 lasI rhlI, in which the signal-generating parts of the quorum sensing systems are defective were compared...

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PMID: 11320114
DOI: 10.1099/00221287-147-5-1105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11320114-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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