Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.

doi:10.1093/hmg/8.2.267

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Article

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.

Human molecular genetics - 1 Feb 1999

Gutmann D H, Sherman L, Seftor L, Haipek C, Hoang Lu K, Hendrix M

Abstract excerpt

The neurofibromatosis 2 ( NF2 ) gene product, merlin, is a tumor suppressor protein mutated in schwanno-mas and several other tumors. Merlin, which shares significant homology with the actin-associated proteins ezrin, radixin and moesin (ERM proteins), inhibits cell growth when overexpressed in c...

Topics

Animals
Cell Adhesion
Cell Division
Cell Movement
Cytoskeletal Proteins
Gene Expression Regulation, Neoplastic
Genes, Neurofibromatosis 2
Genes, Tumor Suppressor
Membrane Proteins
Microfilament Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurofibromin 2

Phosphoproteins

Trans-Activators

Tumor Cells, Cultured

alpha Catenin

beta Catenin

Source

Open in PubMed

Identifiers

PMID: 9931334
DOI: 10.1093/hmg/8.2.267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9931334-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.PMID 9931334Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

Merlin differentially associates with the microtubule and actin cytoskeletonSemantic proximity Read ↗

<i>NF2</i>: The wizardry of merlinSemantic proximity Read ↗

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations.Semantic proximity Read ↗

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

Merlin inhibits neurite outgrowth in the CNS.Semantic proximity Read ↗

Neurofibromatosis 2: loss of merlin's protective spell.Semantic proximity Read ↗

Merlin is a potent inhibitor of glioma growth.Semantic proximity Read ↗

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