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Article

A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA.

Nucleic acids research - 1 Dec 2017

Kanazawa Hiroki, Baba Fumika, Koganei Mai, Kondo Jiro

Abstract excerpt

The aminoglycoside resistance conferred by an N1-methylation of A1408 in 16S rRNA by a novel plasmid-mediated methyltransferase NpmA can be a future health threat. In the present study, we have determined crystal structures of the bacterial ribosomal decoding A site with an A1408m1A antibiotic-resistance mutation both in the presence and absence of aminoglycosides. G418 and paromomycin both possessing a 6'-OH...

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Identifiers

PMID: 29036479
DOI: 10.1093/nar/gkx882
PMCID: PMC5716097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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