Accelerated evolution and molecular surface of venom phospholipase A2 enzymes.

doi:10.1007/pl00006450

Back to search

Article

Accelerated evolution and molecular surface of venom phospholipase A2 enzymes.

Journal of molecular evolution - 1 Feb 1999

Kini R M, Chan Y M

Abstract excerpt

Multiple phospholipase A2 (PLA2) isoenzymes found in a single snake venom induce a variety of pharmacological effects. These multiple forms are formed by gene duplication and accelerated evolution of exons. We examined the amino acid sequences of 127 snake venom PLA2 enzymes and their homologues...

Topics

Amino Acid Sequence
Amino Acid Substitution
Evolution, Molecular
Molecular Sequence Data
Mutation
Phospholipases A
Phospholipases A2
Protein Structure, Tertiary
Snake Venoms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.