Article
Target-Driven Evolution of Scorpion Toxins.
Scientific reports - 7 Oct 2015
Zhang Shangfei, Gao Bin, Zhu Shunyi
Abstract excerpt
It is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their adaptive evolution remains a mystery. By using maximum-likelihood models of codon substitution, we analyzed molecular adaptation in scorpion sodium channel toxins from a specific species and found ten positively selected sites, six of which...
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