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Article

Molecular evolution of myotoxic phospholipases A2 from snake venom.

Toxicon : official journal of the International Society on Toxinology - 15 Dec 2003

Ohno Motonori, Chijiwa Takahito, Oda-Ueda Naoko, Ogawa Tomohisa, Hattori Shosaku

Abstract excerpt

After two decades of study, we draw the conclusion that venom-gland phospholipase A2 (PLA2) isozymes, including PLA2 myotoxins of Crotalinae snakes, have evolved in an accelerated manner to acquire their diverse physiological activities. In this review, we describe how accelerated evolution of venom PLA2 isozymes was discovered. This type of evolution is fundamental for other venom isozyme systems. Accelerated...

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Identifiers

PMID: 15019486
DOI: 10.1016/j.toxicon.2003.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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