Article
Replacement and Parallel Simplification of Nonhomologous Proteinases Maintain Venom Phenotypes in Rear-Fanged Snakes.
Molecular biology and evolution - 16 Dec 2020
Bayona-Serrano Juan David, Viala Vincent Louis, Rautsaw Rhett M, Schramer Tristan D, Barros-Carvalho Gesiele A, Nishiyama Milton Yutaka, Freitas-de-Sousa Luciana A, Moura-da-Silva Ana Maria, Parkinson Christopher L, Grazziotin Felipe Gobbi, Junqueira-de-Azevedo Inácio L M
Abstract excerpt
Novel phenotypes are commonly associated with gene duplications and neofunctionalization, less documented are the cases of phenotypic maintenance through the recruitment of novel genes. Proteolysis is the primary toxic character of many snake venoms, and ADAM metalloproteinases, named snake venom metalloproteinases (SVMPs), are largely recognized as the major effectors of this phenotype. However, by investigating...
Topics
- Animals
- Evolution, Molecular
- Matrix Metalloproteinases
- Phenotype
- Proteolysis
- Snake Venoms
- Snakes
- Transcriptome