Article
Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis.
Toxicon : official journal of the International Society on Toxinology - 15 Dec 2003
Chioato Lucimara, Ward Richard J
Abstract excerpt
In addition to their catalytic activity, snake venom phospholipases A2 (vPLA2) present remarkable diversity in their biological effects. Sequence alignment analyses of functionally related PLA2 are frequently used to predict the structural determinants of these effects, and the predictions are su...
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