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Article

X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy

1 Jan 2021

Abstract excerpt

Abstract Sudden Unexpected Death in Epilepsy is a leading cause of epilepsy-related mortality, and the analysis of mouse Sudden Unexpected Death in Epilepsy models is steadily revealing a spectrum of inherited risk phenotypes based on distinct genetic mechanisms. Serotonin (5-HT) signalling enhances post-ictal cardiorespiratory drive and, when elevated in the brain, reduces death following evoked audiogenic...

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PMID: 34396109
DOI: 10.1093/braincomms/fcab149

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