Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2002

Frank Marcos G, Stryker Michael P, Tecott Laurence H

Abstract excerpt

Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Receptors, Serotonin
Share to Electroencephalography

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeostasis

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Receptor, Serotonin, 5-HT2C

Share to Sleep Deprivation

Source

Open in PubMed Open full text

Identifiers

PMID: 12431861
DOI: 10.1016/S0893-133X(02)00353-6
PMCID: PMC2452994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.PMID 12431861Read ↗

Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice.Semantic proximity Read ↗

The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.Semantic proximity Read ↗

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.Semantic proximity Read ↗

X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsySemantic proximity Read ↗

A sleep-promoting role for the Drosophila serotonin receptor 1A.Semantic proximity Read ↗

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

The genetic and molecular regulation of sleep: from fruit flies to humans.Semantic proximity Read ↗

Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin.Semantic proximity Read ↗

Sleep and wakefulness in Drosophila melanogaster.Semantic proximity Read ↗

Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors.Semantic proximity Read ↗

Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.