Article
Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2002
Frank Marcos G, Stryker Michael P, Tecott Laurence H
Abstract excerpt
Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an...
Topics
- Animals
- Electroencephalography
- Homeostasis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
- Sleep