Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.

doi:10.1038/ng0897-387

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Article

Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.

Nature genetics - 1 Aug 1997

Brennan T J, Seeley W W, Kilgard M, Schreiner C E, Tecott L H

Abstract excerpt

The epilepsies are a heterogeneous collection of seizure disorders with a lifetime expectancy risk rate of 2-4%. A convergence of evidence indicates that heritable factors contribute significantly to seizure susceptibility. Genetically epilepsy-prone rodent strains have been frequently used to ex...

Topics

Acoustic Stimulation
Animals
Brain
Disease Models, Animal
Escape Reaction
Female
Male
Mice
Mice, Inbred C57BL
Mutation
Receptor, Serotonin, 5-HT2C
Receptors, Serotonin
Seizures
Sound

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