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Article

Autocrine inhibition of mitotic activity in cultured oligodendrocyte-type-2 astrocyte (O-2A) precursor cells.

Glia - 1 Jan 1992

Louis J C, Muir D, Varon S

Abstract excerpt

During development, oligodendrocytes are generated from a bipotential glial stem cell, the oligodendrocyte-type-2 astrocyte precursor (O-2A). O-2A cells are under the mitogenic influence of the platelet-derived growth factor (PDGF) released from type-1 astrocytes. In vitro experiments have shown that O-2A cells stimulated by PDGF are limited to a set number of divisions and then differentiate to oligodendrocytes...

Topics

Animals
Animals, Newborn
Astrocytes
Cell Division
Cell Line
Cerebral Cortex
Culture Media
Immunohistochemistry
Mitogens
Mitosis
Oligodendroglia
Phenotype

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Identifiers

PMID: 1387386
DOI: 10.1002/glia.440060105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1387386-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Autocrine inhibition of mitotic activity in cultured oligodendrocyte-type-2 astrocyte (O-2A) precursor cells.PMID 1387386Read ↗

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