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Article

Expression of BCR - ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation.

Oncogene - 14 Jan 1999

Cambier N, Zhang Y, Vairo G, Kosmopoulos K, Metcalf D, Nicola N A, Elefanty A G

Abstract excerpt

The mechanism leading to the expanding population of maturing myeloid cells which characterises chronic myeloid leukemia (CML) remains obscure. Because of its ability to mimic the proliferative and cell survival functions of hematopoietic growth factors, we hypothesized that the oncogene activated in CML, BCR-ABL, might also influence differentiation. To test this hypothesis, we examined the effects of expressing...

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Identifiers

PMID: 9927191
DOI: 10.1038/sj.onc.1202302

Genes

BCR
LIF
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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