Article
Expression of BCR - ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation.
Oncogene - 14 Jan 1999
Cambier N, Zhang Y, Vairo G, Kosmopoulos K, Metcalf D, Nicola N A, Elefanty A G
Abstract excerpt
The mechanism leading to the expanding population of maturing myeloid cells which characterises chronic myeloid leukemia (CML) remains obscure. Because of its ability to mimic the proliferative and cell survival functions of hematopoietic growth factors, we hypothesized that the oncogene activate...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- Cell Division
- Clone Cells
- Dexamethasone
- Fusion Proteins, bcr-abl
- Growth Inhibitors
- Interleukin-6
- Leukemia Inhibitory Factor
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphokines
- Macrophages
- Mice
- Phenotype
- Proto-Oncogene Proteins c-myc
- RNA, Messenger
- Tumor Cells, Cultured