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Article

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells.

Stem cell reports - 14 Feb 2017

Cirovic Branko, Schönheit Jörg, Kowenz-Leutz Elisabeth, Ivanovska Jelena, Klement Christine, Pronina Nina, Bégay Valérie, Leutz Achim

Abstract excerpt

The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of any C/EBP, and enhanced by endogenous C/EBPα and β activation. High transgene expression of C/EBPβ or C/EBPε, but not of C/EBPα or C/EBPδ, also induced the formation of...

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Source

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Identifiers

PMID: 28111277
DOI: 10.1016/j.stemcr.2016.12.015
PMCID: PMC5312250

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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