Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

15 Apr 1994

Abstract excerpt

BCR-ABL expression is presumed to effect clonal expansion in chronic myeloid leukemia (CML) by deregulation of cell proliferation. However, most studies have found that relative rates of cell proliferation are not increased in CML. Moreover, we found that CML progenitors display a normal proliferative response to growth factors and do not manifest greater proliferative potential than normal progenitors. Growth of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Chronic Myeloid Leukemia Treatments
Share to Eosinophilic Disorders and Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8161775
DOI: 10.1182/blood.v83.8.2038.2038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemiaPMID 8161775Read ↗

Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic ProgenitorsSemantic proximity Read ↗

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense OligodeoxynucleotidesSemantic proximity Read ↗

The stem cell factor–c-KIT pathway must be inhibited to enable apoptosis induced by BCR–ABL inhibitors in chronic myelogenous leukemia cellsSemantic proximity Read ↗

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemiaSemantic proximity Read ↗

BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors.Semantic proximity Read ↗

Punish the parent not the progenySemantic proximity Read ↗

Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinibSemantic proximity Read ↗

Re-evaluating the role of BCR/ABL in chronic myelogenous leukemiaSemantic proximity Read ↗

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fateSemantic proximity Read ↗

Molecular Abnormalities in Chronic Myeloid Leukemia: Deregulation of Cell Growth and ApoptosisSemantic proximity Read ↗

Primitive, Quiescent and Difficult to Kill: The Role of Non-Proliferating Stem Cells in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Curcumin Affects Components of the Chromosomal Passenger Complex and Induces Mitotic Catastrophe in Apoptosis-Resistant Bcr-Abl-Expressing CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.