In Vivo Emergence of Multidrug-Resistant Mutants of<i>Pseudomonas aeruginosa</i>Overexpressing the Active Efflux System MexA-MexB-OprM

Abstract excerpt

During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal beta-lactam antibiotics were isolated from hospitalized patients. In vivo emergence of beta-lactam resistance was associated with the overexpression of AmpC beta-lactamase in 10 patients. In the other 11 patients, the posttherapy isolates produced only low, basal levels of...

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