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Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in <i>Pseudomonas aeruginosa</i> : Novel Agents for Combination Therapy

1 Jan 2001

Abstract excerpt

Whole-cell assays were implemented to search for efflux pump inhibitors (EPIs) of the three multidrug resistance efflux pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN) that contribute to fluoroquinolone resistance in clinical isolates of Pseudomonas aeruginosa. Secondary assays were developed to identify lead compounds with exquisite activities as inhibitors. A broad-spectrum EPI which is active against all three...

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PMID: 11120952
DOI: 10.1128/aac.45.1.105-116.2001

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