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Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.

Antimicrobial agents and chemotherapy - 1 May 2004

Llanes Catherine, Hocquet Didier, Vogne Christelle, Benali-Baitich Dounia, Neuwirth Catherine, Plésiat Patrick

Abstract excerpt

Simultaneous overexpression of the MexAB-OprM and MexXY efflux systems was demonstrated by real-time reverse transcription-PCR and immunoblotting experiments for 12 multiresistant clinical isolates of Pseudomonas aeruginosa. DNA sequencing analysis showed that nine of these strains (named agrZ mutants) harbored mutations in mexZ, the product of which downregulates the expression of the mexXY operon. In addition,...

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Identifiers

PMID: 15105137
DOI: 10.1128/AAC.48.5.1797-1802.2004
PMCID: PMC400543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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