Article
[Two efflux systems expressed simultaneously in clinical Pseudomonas aeruginosa].
Pathologie-biologie - 1 Oct 2004
Hocquet D, Llanes C, Patry I, El Garch F, Plésiat P
Abstract excerpt
Active efflux systems MexAB-OprM and MexXY were found to be overexpressed simultaneously in 12 multiresistant clinical isolates of Pseudomonas aeruginosa. Nine of these strains (agrZ mutants) harbored mutations in gene mexZ, the product of which down-regulates expression of operon mexXY. Eight of the 12 strains exhibited mutations in genes known to control transcription of operon mexAB-oprM, such as mexR (four...
Topics
- Anti-Bacterial Agents
- Drug Resistance, Multiple
- Humans
- Microbial Sensitivity Tests
- Mutation
- Operon
- Pseudomonas Infections
- Pseudomonas aeruginosa
- Transcription, Genetic