Article
Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy - 1 Jun 2001
De Kievit T R, Parkins M D, Gillis R J, Srikumar R, Ceri H, Poole K, Iglewski B H, Storey D G
Abstract excerpt
Pseudomonas aeruginosa biofilms are intrinsically resistant to antimicrobial chemotherapies. At present, very little is known about the physiological changes that occur during the transition from the planktonic to biofilm mode of growth. The resistance of P. aeruginosa biofilms to numerous antimicrobial agents that are substrates subject to active efflux from planktonic cells suggests that efflux pumps may...
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