Article
Simultaneous overexpression of multidrug efflux pumps in Pseudomonas aeruginosa non-cystic fibrosis clinical isolates.
Canadian journal of microbiology - 1 Jul 2014
Poonsuk Kanchana, Tribuddharat Chanwit, Chuanchuen Rungtip
Abstract excerpt
The purpose of this study was to examine expression and regulation of 6 multidrug efflux systems, including MexAB-OprM, MexCD-OprJ, MexEF-OprN, MexXY, MexJK, and MexVW, in 13 non-cystic fibrosis (CF) clinical isolates of Pseudomonas aeruginosa. These isolates displayed a high level of resistance to many clinically important antibiotics. Some isolates simultaneously overexpressed up to 4 different Mex systems, as...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Drug Resistance, Multiple
- Gene Expression Regulation, Bacterial
- Genes, Regulator
- Membrane Transport Proteins
- Mutation
- Pseudomonas Infections
- Pseudomonas aeruginosa
- RNA, Bacterial