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Article

Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax.

The Journal of biological chemistry - 21 Oct 2005

Kwon Hakju, Ogle Louise, Benitez Bobby, Bohuslav Jan, Montano Mauricio, Felsher Dean W, Greene Warner C

Abstract excerpt

Type I human T cell leukemia virus (HTLV-I) is etiologically linked with adult T cell leukemia, an aggressive and usually fatal expansion of activated CD4+ T lymphocytes that frequently traffic to skin. T cell transformation induced by HTLV-I involves the action of the 40-kDa viral Tax transactivator protein. Tax both stimulates the HTLV-I long terminal repeat and deregulates the expression of select cellular...

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Identifiers

PMID: 16105841
DOI: 10.1074/jbc.M504848200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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