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Article

Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model.

Journal of virology - 1 Mar 2001

Portis T, Grossman W J, Harding J C, Hess J L, Ratner L

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL). The HTLV-1 Tax protein has been strongly linked to oncogenesis and is considered to be the transforming protein of this virus. A Tax transgenic mouse model was utilized to study the contribution of p53 inactivation to Tax-mediated tumorigenesis. These mice develop primary, peripheral tumors consisting of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia-Lymphoma, Adult T-Cell

Share to Polymorphism, Single-Stranded Conformational

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 11160722
DOI: 10.1128/JVI.75.5.2185-2193.2001
PMCID: PMC114802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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