Article
[Polymorphism of N-acetyltransferase-2 and pathogenesis of neoplastic diseases].
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 1 Jan 2005
Kłodowska-Duda Gabriela A, Samelska Justyna A, Opala Grzegorz M
Abstract excerpt
Pathogenesis of many diseases is connected with influence of environmental factors with individual genetic sensitivity dependent among others on detoxification enzymes. Mutations of N-acetyltransferase-2 lead to decreased enzyme function. In this review the focus is on discussion about the connection between the polymorphic N-acetyltransferase-2 and increase in the risk of cancer, atopic disease and adverse drug...
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