Article
Novel attributes of an androgenic steroid-mediated increase in cardiac end diastolic stiffness in rats.
Canadian journal of physiology and pharmacology - 1 Jun 1998
Trifunovic B, Woodiwiss A J, Duffield M, Norton G R
Abstract excerpt
Although cardiac early and mid-diastolic stiffness constants are well accepted as being modulated by alterations in myocyte active processes, increments in left ventricular end diastolic (LVED) stiffness (LVED k; g x cm(-2)) in classical pathological models of a reduced LVED k (e.g., diabetes mel...
Topics
- Androgens
- Animals
- Collagen
- Diabetes Mellitus, Experimental
- Diastole
- Extracellular Matrix
- Heart
- Hemodynamics
- Myocardial Contraction
- Phenotype
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Rats, Sprague-Dawley
- Solubility
- Spectrometry, Fluorescence
- Steroids
- Ventricular Function, Left