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Article

GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension.

American journal of physiology. Heart and circulatory physiology - 15 Apr 2016

Liu Liu, Kashyap Shreya, Murphy Brennah, Hutson Dillion D, Budish Rebecca A, Trimmer Emma H, Zimmerman Margaret A, Trask Aaron J, Miller Kristin S, Chappell Mark C, Lindsey Sarah H

Abstract excerpt

The mRen2 female rat is an estrogen- and salt-sensitive model of hypertension that reflects the higher pressure and salt sensitivity associated with menopause. We previously showed that the G protein-coupled estrogen receptor (GPER) mediates estrogenic effects in this model. The current study hypothesized that GPER protects against vascular injury during salt loading. Intact mRen2 female rats were fed a normal...

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Identifiers

PMID: 26873963
DOI: 10.1152/ajpheart.00631.2015
PMCID: PMC4867339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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