Article
Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats.
Circulation - 16 Sept 1997
Norton G R, Tsotetsi J, Trifunovic B, Hartford C, Candy G P, Woodiwiss A J
Abstract excerpt
BACKGROUND: The relative contributions of increases in myocardial collagen, collagen cross-linking, and the ratio of type I to type III collagen to the stiff myocardium in hypertension were determined. METHODS AND RESULTS: We compared the action of hydralazine (0.07 mmol x kg(-1) x d(-1)) with th...
Topics
- Animals
- Antihypertensive Agents
- Body Weight
- Captopril
- Collagen
- Cross-Linking Reagents
- Diastole
- Disease Models, Animal
- Hydralazine
- Hypertension
- Male
- Myocardium
- Organ Size
- Phenotype
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Solubility