Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function.

doi:10.1016/j.phrs.2006.12.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function.

Pharmacological research - 1 Apr 2007

Osadchii Oleg, Norton Gavin, Deftereos Dawn, Woodiwiss Angela

Abstract excerpt

Sprague-Dawley (SD) rats have been reported to have a higher sympathetic activity than Wistar-Kyoto (WKY) rats. In the present study we sought to determine if these rat strain-related differences in sympathetic activity exist at a myocardial level and whether they translate into changes in cardiac fibrosis, contractile responsiveness to adrenergic agonists, and cardiac structure and function. Coronary effluent...

Topics

Adrenergic Agonists
Animals
Blood Pressure
Cell Size
Diastole
Dose-Response Relationship, Drug
Heart
Heart Rate
Heart Ventricles
Hydroxyproline
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Myocardial Contraction

Myocardium

Myocytes, Cardiac

Norepinephrine

Organ Size

Phenotype

Source

Open in PubMed

Identifiers

PMID: 17257851
DOI: 10.1016/j.phrs.2006.12.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function.PMID 17257851Read ↗

Isoproterenol-induced Cardiac Dysfunction in Male and Female C57Bl/6 MiceSemantic proximity Read ↗

Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat.Semantic proximity Read ↗

Comparison Of Cardiovascular Characteristics In Normotensive And Hypertensive Rat Strains.Semantic proximity Read ↗

Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological SexSemantic proximity Read ↗

Comparative studies in experimental hypertension and cardiac failureSemantic proximity Read ↗

Adaptation to exercise-induced stress is not dependent on cardiomyocyte α1A-adrenergic receptors.Semantic proximity Read ↗

Old mice have a functionally distinct contractile reserve from obese miceSemantic proximity Read ↗

Next Generation of Spontaneously Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop Cardiac Dysfunction and Compromised Cardiac ReserveSemantic proximity Read ↗

Novel attributes of an androgenic steroid-mediated increase in cardiac end diastolic stiffness in rats.Semantic proximity Read ↗

Heart rate and heart rate variability, a pharmacological target.Semantic proximity Read ↗

Increased cardiac norepinephrine release in spontaneously hypertensive rats: role of presynaptic alpha-2A adrenoceptors.Semantic proximity Read ↗

Comprehensive phenotyping of salt-induced hypertensive heart disease in living mice using cardiac magnetic resonance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.