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Article

Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function.

Pharmacological research - 1 Apr 2007

Osadchii Oleg, Norton Gavin, Deftereos Dawn, Woodiwiss Angela

Abstract excerpt

Sprague-Dawley (SD) rats have been reported to have a higher sympathetic activity than Wistar-Kyoto (WKY) rats. In the present study we sought to determine if these rat strain-related differences in sympathetic activity exist at a myocardial level and whether they translate into changes in cardiac fibrosis, contractile responsiveness to adrenergic agonists, and cardiac structure and function. Coronary effluent...

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Source

Identifiers

PMID: 17257851
DOI: 10.1016/j.phrs.2006.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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