Article
The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans.
Journal of bacteriology - 1 Feb 1999
Alarco A M, Raymond M
Abstract excerpt
Candida albicans is an opportunistic pathogenic yeast which frequently develops resistance to the antifungal agent fluconazole (FCZ) in patients undergoing long-term therapy. FCZ-resistant strains often display a reduced intracellular FCZ accumulation which correlates with the overexpression of t...
Topics
- Antifungal Agents
- Brefeldin A
- Candida albicans
- Candidiasis
- Cerulenin
- Chromosomes, Fungal
- Diamide
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Fluconazole
- Gene Deletion
- Genotype
- Homozygote
- Humans
- Oxidative Stress
- Transcription Factor AP-1
- Transcription Factors
- Transcription, Genetic