Article
The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans.
Journal of bacteriology - 1 Feb 1999
Alarco A M, Raymond M
Abstract excerpt
Candida albicans is an opportunistic pathogenic yeast which frequently develops resistance to the antifungal agent fluconazole (FCZ) in patients undergoing long-term therapy. FCZ-resistant strains often display a reduced intracellular FCZ accumulation which correlates with the overexpression of the ATP-binding cassette transporters CDR1 and CDR2 or the major facilitator (MF) MDR1. We have recently cloned a C....
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