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Article

Induced expression of theCandida albicans multidrug resistance geneCDR1 in response to fluconazole and other antifungals

30 Apr 1998

Abstract excerpt

The Candida albicans CDR1 gene encodes a member of the ABC-type family of multidrug transporters which has been shown to be involved in azole resistance. Using an in-frame gene fusion between the CDR1 open reading frame and the green fluorescent protein allele yEGFP3, an optimized derivative for its use in C. albicans, we show here how the CDR1-yEGFP3 gene expression is induced in response to azoles as well as to...

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PMID: 9605502
DOI: 10.1002/(sici)1097-0061(19980430)14:6<517::aid-yea250>3.0.co;2-d

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