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Article

SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1.

Antimicrobial agents and chemotherapy - 1 Sept 2014

Ramírez-Zavala Bernardo, Mogavero Selene, Schöller Eva, Sasse Christoph, Rogers P David, Morschhäuser Joachim

Abstract excerpt

Overexpression of the multidrug efflux pump MDR1 is one mechanism by which the pathogenic yeast Candida albicans develops resistance to the antifungal drug fluconazole. The constitutive upregulation of MDR1 in fluconazole-resistant, clinical C. albicans isolates is caused by gain-of-function muta...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candida albicans

Share to Drug Resistance, Multiple, Fungal

Share to Fluconazole

Share to Gene Expression Regulation, Fungal

Share to Hydrogen Peroxide

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 24936593
DOI: 10.1128/AAC.03065-14
PMCID: PMC4135829

Genes

ADA
ADA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24936593-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1.PMID 24936593Read ↗

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