Article
Persistent polyclonal B-cell lymphocytosis: further evidence for a genetic disorder associated with B-cell abnormalities.
British journal of haematology - 1 Sept 2001
Delage R, Jacques L, Massinga-Loembe M, Poulin J, Bilodeau D, Mignault C, Leblond P F, Darveau A
Abstract excerpt
Persistent polyclonal B-cell lymphocytosis (PPBL) is an intriguing disorder diagnosed predominantly in women, usually cigarette smokers, characterized by an increase in the number of polyclonal B lymphocytes. Abnormality of the B-cell population is also evidenced by the presence of multiple bcl-2/Ig gene rearrangements and the finding of an additional long arm chromosome 3q+ (i3)(q10) within a significant...
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