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Article

B-cell signaling in persistent polyclonal B lymphocytosis (PPBL).

Immunology and cell biology - 1 Oct 2016

Voelxen Nadine, Wehr Claudia, Gutenberger Sylvia, Keller Baerbel, Erlacher Miriam, Dominguez-Conde Cecilia, Bertele Daniela, Emmerich Florian, Pantic Milena, Jennings Stefanie, Rakhmanov Mirzokhid, Foerster Christian, Martens Uwe M, Platzbecker Uwe, Peter Hans-Hartmut, Fisch Paul, Boztug Kaan, Eibel Hermann, Salzer Ulrich, Warnatz Klaus

Abstract excerpt

Persistent polyclonal B lymphocytosis (PPBL) is a benign hematological disorder characterized by a selective expansion of circulating polyclonal marginal zone (MZ)-like B cells. Previous reports demonstrated that cases of PPBL showed poor activation, proliferation and survival of B cells in vitro, yet the underlying defect remains unknown. Here we report for the first time an attenuated activation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27126628
DOI: 10.1038/icb.2016.46

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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