Article
Evolutionary trace analysis of the Kunitz/BPTI family of proteins: functional divergence may have been based on conformational adjustment.
Journal of molecular biology - 29 Jan 1999
Pritchard L, Dufton M J
Abstract excerpt
The structural and functional evolution of the Kunitz/bovine pancreatic trypsin inhibitor (BPTI) family of proteins, which includes serine proteinase inhibitors and potassium channel blockers, was analysed with the evolutionary trace method. This method highlights sites in aligned primary sequenc...
Topics
- Amino Acid Sequence
- Animals
- Aprotinin
- Binding Sites
- Cattle
- Conserved Sequence
- Elapid Venoms
- Evolution, Molecular
- Genetic Variation
- Humans
- Models, Molecular
- Molecular Sequence Data
- Phylogeny
- Protein Conformation
- Protein Engineering
- Protein Folding
- Sequence Homology, Amino Acid