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Article

Imprint of evolutionary conservation and protein structure variation on the binding function of protein tyrosine kinases.

Bioinformatics (Oxford, England) - 1 Aug 2006

Verkhivker Gennady M

Abstract excerpt

MOTIVATION: According to the models of divergent molecular evolution, the evolvability of new protein function may depend on the induction of new phenotypic traits by a small number of mutations of the binding site residues. Evolutionary relationships between protein kinases are often employed to infer inhibitor binding profiles from sequence analysis. However, protein kinases binding profiles may display...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16720585
DOI: 10.1093/bioinformatics/btl199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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