Article
Evolutionary mechanisms acting on proteinase inhibitor variability.
The FEBS journal - 1 Nov 2005
Christeller John T
Abstract excerpt
The interaction of proteinase inhibitors produced, in most cases, by host organisms and the invasive proteinases of pathogens or parasites or the dietary proteinases of predators, results in an evolutionary 'arms race' of rapid and ongoing change in both interacting proteins. The importance of these interactions in pathogenicity and predation is indicated by the high level and diversity of observable evolutionary...
Topics
- Amino Acid Sequence
- Animals
- Endopeptidases
- Endoribonucleases
- Evolution, Molecular
- Gene Duplication
- Genes
- Genetic Variation
- Mutation
- Parasites
- Protease Inhibitors
- Protein Folding