Article
A despecialization step underlying evolution of a family of serine proteases.
Molecular cell - 1 Aug 2003
Wouters Merridee A, Liu Ke, Riek Peter, Husain Ahsan
Abstract excerpt
In the trypsin superfamily of serine proteases, non-trypsin-like primary specificities have arisen in only two monophyletic descendent subbranches. We have recreated an ancestor to one of these subbranches (granzyme) using phylogenetic inference, gene synthesis, and protein expression. This ancestor has two unusual properties. First, it has broad primary specificity encompassing the entire repertoire of novel...
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