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Article

Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.

Expert review of hematology - 1 Oct 2012

Nurden Alan T, Pillois Xavier, Nurden Paquita

Abstract excerpt

Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction. Despite...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23146053
DOI: 10.1586/ehm.12.46

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.PMID 23146053Read ↗

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