Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.

doi:10.1586/ehm.12.46

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Article

Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment.

Expert review of hematology - 1 Oct 2012

Nurden Alan T, Pillois Xavier, Nurden Paquita

Abstract excerpt

Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction. Despite...

Topics

Humans
Integrin alpha2
Integrin alphaVbeta3
Integrin beta3
Mutation
Platelet Aggregation
Polymorphism, Single Nucleotide
Protein Structure, Tertiary
Thrombasthenia

Source

Open in PubMed

Identifiers

PMID: 23146053
DOI: 10.1586/ehm.12.46

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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